Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Since Tylenol is such a hot topic right now, did you know it depletes glutathione levels? When your body processes Tylenol in the liver, one of the pathways creates a toxic byproduct. To neutralize Frontiers Acetaminophen induced liver injury: Molecular mechanism and treatments from natural products g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Taking Tylenol? The Glutathione Connection Dr. Green Mom