Can Tylenol (acetaminophen) deplete glutathione levels in the body? Chronic acetaminophen ingestion resulting in severe anion gap metabolic acidosis secondary to 5 oxoproline accumulation: an under diagnosed phenomenon BMJ Case Reports PDF) Erratum to: The effects of acute acetaminophen toxicity on hepatic mRNA expression of SOD, CAT, GSH Px, and levels of peroxynitrite, nitric oxide, reduced glutathione, and malondialdehyde in rabbit Acetaminophen, also known as Tylenol, is used to help with pain & to reduce fever. However, taking too much acetaminophen can be harmful to the liver which filters out toxins & Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect The Hidden Impact of Acetaminophen Well Rooted